Axillary lymph node sampling (LAS) is a recent advance in early breast cancer detection, involving sampling of a few lymph nodes from the axilla to detect cancerous cells. This study compared sentinel lymph node biopsy (SLNB) and LAS in predicting axillary node status in clinically node-negative operable breast cancer patients. A prospective study was conducted among 50 patients. LAS involved a 2 cm incision in the middle third of the axillary clearance area, dissecting all fat and tissue in a 2 cm diameter. LAS demonstrated 97.5% sensitivity, 64.5% specificity, 91.5% positive predictive value, 89.7% negative predictive value, and 90% accuracy. The results indicate that SLNB and LAS are equally accurate, and LAS may be preferred in developing countries due to resource and equipment constraints.