Predictive medicinal metabolites fromMomordica dioicaagainst comorbidity related proteins of SARS-CoV-2 infections

Dimensions

Sakshi, Chavan and Harikrishnan, A. and Jayaraman, Selvakumar and Choudhury, Ahana Roy and Veena, V. (2022) Predictive medicinal metabolites fromMomordica dioicaagainst comorbidity related proteins of SARS-CoV-2 infections. Journal of Biomolecular Structure and Dynamics, 40 (11). pp. 5175-5188. ISSN 0739-1102

Full text not available from this repository.

Abstract

Momordica dioica bioactive flavonoids and triterpenoids were studied for antiviral, antidiabetic, and immunomodulatory activity against SARS-CoV-2. Molecular docking and in silico ADME analysis showed hederagenin and oleanolic acid had superior binding to viral proteins (Mpro, RdRp, spike, ACE2, DPP4) compared to catechin, quercetin, and standard drugs. Quercetin demonstrated good safety and gastrointestinal permeability. The study indicates M. dioica compounds have therapeutic potential against SARS-CoV-2 infections, particularly under comorbid conditions. © 2022 Elsevier B.V., All rights reserved.

Item Type: Article
Subjects: Pharmacology, Toxicology and Pharmaceutics > Drug Discovery
Divisions: Arts and Science > School of Arts and Science, Chennai > Chemistry
Depositing User: Unnamed user with email techsupport@mosys.org
Last Modified: 02 Dec 2025 09:40
URI: https://vmuir.mosys.org/id/eprint/3045

Actions (login required)

View Item
View Item