Identification of differentially methylated candidate genes and their biological significance in IUGR neonates by methylation EPIC array

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Krishna, Rao Gurugubelli and Vishnu Bhat, Ballambattu and Bobby, Zachariah and Papa, Dasari and Badhe, Bhawana and Kalidoss, Vinoth Kumar and Karli, Sreenivasulu (2022) Identification of differentially methylated candidate genes and their biological significance in IUGR neonates by methylation EPIC array. The Journal of Maternal-Fetal & Neonatal Medicine, 35 (3). pp. 525-533. ISSN 1476-7058

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Abstract

Intrauterine growth restriction (IUGR) is associated with impaired fetal growth and future metabolic disease risk. This study evaluated DNA methylation in 40 IUGR and 40 gestation-matched appropriate for gestational age (AGA) neonates. Umbilical cord blood was collected, and genomic DNA methylation percentage was measured using 5-mC DNA ELISA. IUGR neonates exhibited global hypomethylation (IUGR: 3.12 ± 1.24; AGA: 4.40 ± 2.03; p<0.01), especially in regulatory regions and promoters. Differential methylation of PTPRN2 & HLADQB1 genes affects T-cell regulation and ROS, potentially leading to later complications. © 2022 Elsevier B.V., All rights reserved.

Item Type: Article
Subjects: Engineering > Engineering
Divisions: Medicine > Aarupadai Veedu Medical College and Hospital, Puducherry > Biochemistry
Depositing User: Unnamed user with email techsupport@mosys.org
Last Modified: 02 Dec 2025 09:36
URI: https://vmuir.mosys.org/id/eprint/3027

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