This article addresses asymptotic synchronization of non-identical complex dynamic fractional-order networks with uncertainty. Using the Riemann–Liouville fractional derivative, a general model for non-identical complex networks was developed. Based on fractional-order calculus and the direct Lyapunov method, drive and response systems were proposed to ensure asymptotic synchronization via neoteric control. Network uncertainties in state matrices were considered, and requirements for asymptotic synchronization were evaluated. Two numerical simulations demonstrate the effectiveness of the approach. © 2022 Elsevier B.V., All rights reserved.