This research work is focusing on the different properties of heat transfer through 3D structures. There are four different level of analysis to find the facts of 3D heat transfer. In the first step, nature and effects of surface radiosity have been analyzed, and it is found that diffuse irradiance (I<inf>diff</inf>) value is 100 [W/m2] for diffuse surface and 0.5 [W/m2] for diffuse mirror. It is also noticed that the effect of surface radiosity which is the same in both the cases, while surface emission (€) value is 0, and 1 is 519 w/m2 (max.). Second step explains about how to quantify the temperature variations which is very helpful for any micro-level devices for better retaining at higher level of temperature. It is also providing the knowledge of thermal stability for different applications like retaining of electronic devices for higher temperature and continuously for long time period. In third step, effort has been done to understand the thermally induced deformation of a plate, and finally, in fourth step, 3D heat transfer and effects of conductivity have been analyzed. After analyzing all these steps, one can use these properties to fabricate the micro- or nano-level devices for different kind of biomedical applications; these kind of devices are very sensitive, and all the parameters can be checked using simulation so that by using micromachining technique novel type of devices can be manufactured which may help to the society to solve many health or environment-related issues. © 2022 Elsevier B.V., All rights reserved.