This research work is addressing the goal of achieving good health and well being of human being by attempting the detection of a target analyte (HIV or other bimolecular analyte) using microcantilever. It is much helpful to detect the bio-analytes because of its high sensitivity, selectivity and structural simplicity. Depending on deflection of microcantilever by achieving maximum displacement, device can be made extremely sensitive. The reason of making the device more sensitive is to detect even a single molecule also. Design has been done in three different stages. In first stage estimated the more suitable and sensitive sensing material. A second stage investigation has been done for the suitable construction of different shapes by introducing different holes in structure. At third stage research has been done about the multilayered to make the device more sensitive. Finally, concentration is to produce a high sensitive structure to detect the analyte quickly. © 2022 Elsevier B.V., All rights reserved.