A huge popularity of biosensors is because of its detection capability of bio molecules. Micro cantilevers are adding some additional features in this detection technique with the help of MEMS (Micro-Electro-Mechanical-Systems) technology. In this paper single, double and 3-strip microcantilevr has been designed and analyzed. The primary principle of this paper is to identify the bio molecule using the deflection of beam. Due to colliding of targeted molecules with sensing layer at free end of the microcantiliver enhancement of weight occurs as a result micro cantilever get bends. This bending provides a very important result that is how to detect the presence of cancer in the blood cells. It may be analyzed either in dynamic or static mode of micro cantilever. This research work is not providing a solution of how to be get cured from this disease but it is providing a suitable solution of how the cancer can be detected at its initial stage using a small amount of blood samples. Since, DNA (Deoxyribonucleic acid) and image based cancer detection techniques are very expensive and complicated; it is why this Micro-Electro-Mechanical Systems based micro cantilever technique has been suggested in this work. Additional advantage is since these devices are micro scale devices, thus very small amount of blood sample is required to test and identify the target molecules. Selection of a suitable sensing material is further additional benefits for this research and it has a huge scope. © 2022 Elsevier B.V., All rights reserved.