SARS-CoV-2 Omicron variant of concern (VOC) has rapidly expanded worldwide since it first emerged on November 24, 2021, in Southern Africa and has already reached every continent. Many issues surrounding Omicron remain unresolved, including the severity of the disease and the extent to which currently available vaccinations effectively prevent COVID-19 infection. Compared to the previous VOC (Delta version), more mutations were detected, which may address Omicron's characteristics. On November 9, 2021, South Africa confirmed the first COVID-19 B.1.1.529 variant. Two confirmed COVID-19 variants of the B.1.1.529 virus were identified in Puducherry, India on November 28, 2021. WHO1 designated this mutation as a Variant of Concern (VOC) and called it “Omicron” to differentiate it from others. According to the experts, a “very unusual constellation of mutations” has been discovered in this new strain of the Omicron virus. Because of its vast mutations and spike protein alteration, the WHO called Omicron a “frightening strain” of coronavirus. The WHO noted more time is needed to determine whether the new coronavirus strain is more infectious than prior strains or if Omicron exposure may worsen patient health. South African experts suspected a novel coronavirus strain, but COVID-19 individuals with the Omicron variation showed minimal symptoms. Another South African doctor says they may be administered at home. South Africa has a record-breaking viral epidemic among people vaccinated by Johnson & Johnson, Covishield, Oxford-AstraZeneca, Covaxin, Novavax, Sinovac, Sinopharm, or Pfizer-Biotech. It's crucial to know whether the current vaccinations will work against this severely modified strain. After South Africa, more than 60 countries had the Omicron version by December 10, 2021. The UK has confirmed the first death caused by the Omicron version. Since the first instance of the Omicron coronavirus was reported in late November 2021, India has documented 1,525 Omicron virus infections in 23 states and union territories to date. The first two Omicron cases were confirmed in the Union Territory of Puducherry on Tuesday, December 28th, just days before the 2022 New Year's celebrations. The new appearance of Omicron triggered new suspicions throughout the world, and people in India, particularly the Puducherry Union Territory people, were once again alarmed due to this drastically muted variation. Currently, Puducherry had only two cases where Maharashtra had the greatest number of COVID-19 instances, with 460, followed by Delhi with 351 cases, Gujarat with 136, Tamil Nadu with 117, and Kerala with 109. Furthermore, Gao, et al. hypothesised that nations with a shaky healthcare system and poor vaccination rates had a greater risk of developing novel coronavirus variants. © 2022 Elsevier B.V., All rights reserved.