BRCA-1 mediated activation of NF-κβ and its pro-inflammatory network drives tumorigenesis in benign breast disease patients

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Jeyakumar, B. and Ambujam, G. and Suganya, K. and Arunagiri, R. (2022) BRCA-1 mediated activation of NF-κβ and its pro-inflammatory network drives tumorigenesis in benign breast disease patients. Human Gene, 33. p. 201060. ISSN 27730441

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Abstract

This study investigated BRCA-1 mutation in benign breast disease (BBD) and breast cancer (CAB) patients. BRCA-1 mutation altered mRNA expression of tumor markers and inflammatory cytokines, with downregulation of P53 and Caspase-3 and upregulation of NF-κβ, BCL-2, COX-2, IL-1β, TNF-α, and IL-6 in BRCA-1 positive patients. Results suggest BRCA-1 mutation contributes to tumor progression and pathogenesis in breast disease.

Item Type: Article
Subjects: Biochemistry, Genetics and Molecular Biology > Cancer Research
Divisions: Medicine > Vinayaka Mission's Medical College and Hospital, Karaikal > Medicine
Depositing User: Unnamed user with email techsupport@mosys.org
Last Modified: 02 Dec 2025 09:12
URI: https://vmuir.mosys.org/id/eprint/2748

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