Pharmacy practice has moved from medication delivery to a patient-focused approach during the last four decades. The pharmacist role has shifted from a compounding pharmacist and distributor of pharmaceuticals to one of the services and finally to a care provider. Progressively, the pharmacist's job is to ensure that the patient's medication is adequate and optimal. Pharmacists play a key role in drug therapy outcomes and overall quality of life. Diabetes affects millions worldwide, particularly in developing countries like India, where delays in diagnosis and management worsen complications and financial burdens. Clinical pharmacists have become essential members of the healthcare team in many medical centers. This article discusses the role of clinical pharmacists in managing diabetes mellitus, including drug therapy management, patient care, and education. The primary aim is to optimize drug therapy to achieve improved clinical outcomes without causing drug-related problems. Well-trained and accessible clinical pharmacists are vital in helping patients achieve better therapeutic outcomes. © 2023 Elsevier B.V., All rights reserved.