In recent years, researchers and health care professionals have been interested in medical image fusion, which combines images of the human body, organs, and cells with general information to address medical difficulties. Computer-aided imaging techniques offer quantitative assessment of images under validation, which helps doctors make unbiased, objective decisions quickly. Multi-sensor and multi-source image fusion models also diversify healthcare analysis characteristics. It led to strong information processing that reveals otherwise invisible details. The fused pictures can help pinpoint anomalies. Multimodal image fusion combines complementing pictures into one. The fused image is ideal for visual perception or computer segmentation, feature extraction, and object recognition. The goal is to create a single fused image with more information than the source photos alone. The fused image combines the source images' complementary and shared elements, delivering enhanced subjective and objective detail. In biomedical imaging, fusing multimodal images has shown useful for disease characterisation. Medical image analysis uses CT, MRI, and PET (PET). In this research paper, we developed a Multimodality Image Fusion using Centre based genetic algorithm (CBGA) and fuzzy logic (FL) technique with lifting wavelet transform (LWT) for fusion of spatially registered MRI and CT images. We also proposed an efficient Multimodality Medical Image Fusion system based on DWT and binary crow search optimization (BCSO) algorithm for fusing MRI and CT images. The performance of the suggested models is validated against many benchmark medical datasets. The experiment showed that the proposed models outperformed all others. © 2023 Elsevier B.V., All rights reserved.