Discordance in genotypic and phenotypic drug susceptibility results: time to reconsider critical concentration of rifampicin

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Shrivas, Arti and Sarman, Singh and Singh, Jitendra P. and Shankar, Prem and Soni, Payal and Rufai, Syed Beenish and Maurya, Anand Kumar and Purwar, Shashank (2025) Discordance in genotypic and phenotypic drug susceptibility results: time to reconsider critical concentration of rifampicin. Microbiology Spectrum, 13 (3). ISSN 21650497

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Abstract

The objective of this study is to correlate rpoB mutations found on next-generation sequencing with minimum inhibitory concentrations...

Item Type: Article
Additional Information: Cited by: 3; All Open Access; Gold Open Access; Green Accepted Open Access; Green Open Access
Uncontrolled Keywords: isoniazid; rifampicin; RNA polymerase beta subunit; bacterial protein; DNA directed RNA polymerase; rpoB protein, Mycobacterium tuberculosis; tuberculostatic agent; antibiotic resistance; antibiotic sensitivity; Article; DNA extraction; fluorometry; gene mutation; gene sequence; genotype; high throughput sequencing; human; minimum inhibitory concentration; multiplex polymerase chain reaction; Mycobacterium tuberculosis; nonhuman; phenotype; quality control; sequence alignment; tuberculosis; drug effect; genetics; isolation and purification; microbial sensitivity test; microbiology; multidrug resistant tuberculosis; mutation; Antitubercular Agents; Bacterial Proteins; DNA-Directed RNA Polymerases; Drug Resistance, Bacterial; Genotype; Humans; Microbial Sensitivity Tests; Mutation; Phenotype; Rifampin; Tuberculosis, Multidrug-Resistant
Subjects: Medicine > Infectious Diseases
Divisions: Medicine > Aarupadai Veedu Medical College and Hospital, Puducherry > Medicine
Depositing User: Unnamed user with email techsupport@mosys.org
Date Deposited: 26 Nov 2025 09:46
Last Modified: 26 Nov 2025 09:46
URI: https://vmuir.mosys.org/id/eprint/256

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