The impact of load, Tomato Methyl Ester (TME), and Exhaust Gas Recirculation (EGR) enriched diesel on engine performance and exhaust gas emissions was examined in this study using the Response Surface Methodology (RSM) optimization technique. TME blend biodiesel (20, 40, and 60%) and EGR (10, 20 and 30%) were selected to maximize BTE and minimize BSFC, NOx, CO, smoke, and HC. The engine was operated using the RSM technique by load (0-100%). The results showed that the response variables were significantly influenced by load, TME and EGR concentration of engine. The results of the constructed quadratic models' analysis of variance (ANOVA) suggested that each model was an appropriate fit. Additionally, an optimal was found by optimizing the user-defined historical design of an experiment. The responses corresponding to optimal study factors were load 100%, TME Blend 20 % and EGR 10% gives maximum BTE of 32.5%. The fuel consumption 0.2 kg/kW.h is reduced when load 50%, TME Blend 60 % and EGR 10%. Smoke andNOx emissions were decreased by 15.09% and 49.04%, while CO and HC emissions were increased by 27.54% and 21.76% © 2023 Elsevier B.V., All rights reserved.