Familial hypercholesterolemia is one of the major causes of cardiovascular diseases, mainly characterized by increased LDL and total cholesterol levels in the blood. It has been established by numerous Genome-Wide Association studies that there are about 64 gene loci that play a significant role in lipid metabolism. These gene loci are considered to be the cause of polygenic FH, in addition to the three major FH-causing genes LDLR, APOB, and PCSK9. Studies by UK-based research groups established that only 6 SNPs are involved in increasing/elevating the LDL cholesterol in the Caucasian population. Based on these findings, we initiated the gene score study using 6 LDL-C-raising SNPs for the first time in the Asian Indian population. Patients with a clinical diagnosis of hypercholesterolemia who did not show any mutations in the major genes were screened for other LDL cholesterol-raising SNPs risk alleles. The subjects with normal lipid profiles and no CVD history were considered a control group in this study. The results revealed that the FH/M- samples had higher mean LDL-C gene risk scores than the controls, although statistically not significant. It is evident from these reports that the Asian cohort needs a separate large population study on this aspect to determine whether to use these gene scores for the prediction of CVD risk or to assess which of these LDL-C-associated SNPs play a crucial role in increasing LDL-C in the Asian population. © 2023 Elsevier B.V., All rights reserved.