Maternal Serum Cyclophilin A: A Predictive Biomarker of Preeclampsia in South Indian Women

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Ponnudhali, D. and Nandhini, N. E. (2025) Maternal Serum Cyclophilin A: A Predictive Biomarker of Preeclampsia in South Indian Women. Journal of Obstetrics and Gynecology of India, 75 (Suppl). 376 - 382. ISSN 09756434; 09719202

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Abstract

Serum Cyclophilin A (CyPA), a chaperone protein released during oxidative stress, was evaluated as a biomarker for preeclampsia in 120 South Indian women. PE patients had significantly elevated CyPA levels (34.58 ± 5.53 ng/mL) compared to healthy pregnancies (7.41 ± 7.7 ng/mL). ROC AUC was 0.971 with 98.33% sensitivity and specificity. CyPA may serve as a novel biomarker for preeclampsia.

Item Type: Article
Additional Information: Cited by: 0
Uncontrolled Keywords: C reactive protein; cyclophilin A; uric acid; adult; area under the curve; Article; baby; birth weight; blood sampling; cohort analysis; controlled study; diagnostic test accuracy study; diastolic blood pressure; disease association; enzyme blood level; enzyme linked immunosorbent assay; fasting; female; follow up; human; India; Indian; major clinical study; maternal serum; medical history; medical school; obstetric delivery; outpatient department; predictive value; preeclampsia; pregnant woman; private hospital; prospective study; protein blood level; protein urine level; quantitative analysis; receiver operating characteristic; second trimester pregnancy; sensitivity and specificity; systolic blood pressure; third trimester pregnancy; uric acid blood level
Subjects: Medicine > Obstetrics and Gynecology
Divisions: Medicine > Vinayaka Mission's Kirupananda Variyar Medical College and Hospital, Salem > Biochemistry
Depositing User: Unnamed user with email techsupport@mosys.org
Date Deposited: 26 Nov 2025 10:04
Last Modified: 26 Nov 2025 10:04
URI: https://vmuir.mosys.org/id/eprint/220

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