An important objective is to develop a biomaterial that can be used as bone-substituted materials with bacterial protection. Calcium-Phosphate and substituted HAP-based ceramic materials are considered as one of the potential candidate for bone and bone-related clinical applications. These ceramics are adequately biocompatible and do not induce adverse local tissue reactions, immunogenicity, or systemic toxicity. Furthermore, since this material is osteoconductive, it acts as a support for new bone formation within the pore sites, which are deliberately generated in the structure. In the biomedicine field, nanoparticles can be used as drug-delivery vehicles that can target tissues or cells and can be functionalized with special characteristics for qualitative or quantitative detection of tumor cells. For these reasons, the scope of the present work is to synthesize Sr-HAP powders with control of size, high quality, purity, and chemical composition by a microwave irradiation method at 720 W by varying aging time as 12 h, 24 h, and 48 h with uniform morphologies. Copyright © 2023, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited. © 2023 Elsevier B.V., All rights reserved.