Postbiotics are biologically active metabolites or components that may be exactly known as waste products synthesized by the probiotic bacteria found in the gut region, which can digest and break down food materials as prebiotics. In this investigation, the yeast Saccharomyces spp. and their metabolites are being analyzed as postbiotics that directly or indirectly enhance the health benefits of hosts as well as improve digestive and immune systems. The biologically active components from Saccharomyces spp., like cell exudates, polysaccharides, enzymes, amino acids, peptides, proteins, fatty acids, vitamins, and other organic compounds, showed different biotherapeutics properties such as pleiotropic effects, immunomodulatory, antiinflammatory, anticancer, and antioxidant activities. The postbiotic components are highly similar to probiotics; they can be able to support the immune system and help to prevent stomach problem like diarrhea, reduce the risk factors related to heart problems, the severity of certain allergies, symptoms associated with irritable bowel diseases, etc. © 2025 Elsevier B.V., All rights reserved.