Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation

Dimensions

Uddandrao, V. V. Sathibabu and Eraniappan, Seshathri and Balakrishnan Ramajayam, Asokan and Singaravel, Sengottuvelu and Roy, Anitha and Parim, Brahma Naidu and Ponnusamy, Chandrasekaran and Ganapathy, Saravanan and Ponnusamy, Ponmurugan and Sasikumar, Vadivukkarasi (2024) Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation. Systems Biology in Reproductive Medicine, 70 (1). pp. 20-37. ISSN 1939-6368

Full text not available from this repository.

Abstract

Oxidative stress, inflammation, and apoptosis in the testes caused by high-fat diets (HFD) are a cause of male infertility. This study investigated the therapeutic efficacy of hydroxycitric acid and capsaicin (HCC) against male reproductive disorders in HFD-induced obese rats. HCC treatment improved sperm quality, testosterone, FSH, LH levels, and activities of steroidogenic enzymes. HCC decreased lipid peroxidation and nitric oxide levels while increasing antioxidant enzyme expression, reducing oxidative stress. HCC also reduced inflammation and apoptosis markers. The study suggests HCC alleviates obesity-induced male reproductive dysfunction by attenuating oxidative stress, inflammation, and apoptosis in testes. © 2024 Elsevier B.V., All rights reserved.

Item Type: Article
Subjects:
Divisions: Medicine > Vinayaka Mission's Kirupananda Variyar Medical College and Hospital, Salem > Biochemistry
Depositing User: Unnamed user with email techsupport@mosys.org
Last Modified: 27 Nov 2025 07:03
URI: https://vmuir.mosys.org/id/eprint/2023

Actions (login required)

View Item
View Item