Background: Managing discomfort after surgery lower abdominal surgery is challenging, impacting recovery and patient well-being. This study compares the efficacy of two abdominis transversus plane (TAP) block formulations—0.25% bupivacaine and 0.25% bupivacaine with dexmedetomidine to optimize analgesia and reduce reliance on systemic medications. Method: Focusing on elective lower abdominal surgeries, the study assesses the formulations’ performance. Key objectives include evaluating time to first rescue analgesia, length of time sensory block, quality of blockade, total rescue analgesia dose within 24 hours, and pain and sedation scores. Result: Critical insights into the comparative performance of TAP block formulations are obtained. Findings encompass time to first rescue analgesia, sensory block duration, blockade quality, rescue analgesia dose, and pain and sedation scores, providing a comprehensive understanding of the effectiveness and potential side effects. Conclusion: This study contributes clinical data to enhance post-operative pain management for lower abdominal surgeries. Anticipated outcomes involve improved patient comfort, quicker recovery, and the potential for more personalized approaches, ultimately advancing patient outcomes and pain management protocols. © 2024 Elsevier B.V., All rights reserved.