Background and Aims: The novel amides bupivacaine and lignocaine are long-acting local anesthetics with distinct blocking properties. The quality of blocking peripheral nerve is enhanced when clonidine is combined with local anesthetics. This investigation aims to evaluate clonidine’s effects on the features of the brachial nerve plexus supraclavicular block induced by ropivacaine. Material and Methods: Two groups of thirty adults each were randomly selected from a total of 60 patients. Group I: About 60 subjects will receive 15 mL each of lignocaine and 0.5% bupivacaine 2% with adrenaline (1:200000) combination. Group II: 30 subjects will receive a mixture of 15 mL each 0.5 and 2% bupivacaine and lignocaine, respectively with adrenaline (1:200000) combined with clonidine (30 mcg). Results: Group II experienced sensorimotor block onset earlier than group I, with sensory block starting at 11.28 ± 1.53 minutes and motor block starting at 9.53 ± 1.32 minutes (19.06 ± 1.7 minutes for blocking sensory nerve and 15.33 ± 2.09 minutes for blocking motor nerve). p < 0.05 determined that both differences were statistically significant. The need for rescue analgesia was significantly higher in group A (p < 0.05). Blocking both sensory and motor nerve blocks occurred more quickly and lasted longer than expected. Hemodynamic measurements, including SPO<inf>2</inf> (oxygen saturation), heartbeat, and cardiovascular blood pressure measurements (systolic and diastolic), did not show any discernible variation. Conclusion: The supraclavicular brachial plexus block quality is greatly improved when clonidine is added to ropivacaine as an adjuvant. This results in a quicker onset of anesthesia, increased post-operative pain relief, an extended period of sensory and motor blockage, and none at all at the dose that is given. © 2024 Elsevier B.V., All rights reserved.