Dimensions
DimensionsChimplee, Siriphorn and Mitsuwan, Watcharapong and Zulkifli, Masyitah and Eawsakul, Komgrit and Ongtanasup, Tassanee and Sangkanu, Suthinee and Mahboob, Tooba and Oliveira, Sonia M.R. and Wiart, Christophe and Ramamoorthy, Siva and Pereira, Maria de Lourdes and Saravanabhavan, Shanmuga Sundar and Wilairatana, Polrat and Nissapatorn, Veeranoot (2024) Comparative efficacy of Knema retusa extract delivery via PEG-b-PCL, niosome, and their combination against Acanthamoeba triangularis genotype T4: characterization, inhibition, anti-adhesion, and cytotoxic activity. PeerJ, 12. e18452. ISSN 2167-8359
Full text not available from this repository.Abstract
Acanthamoeba spp. is a waterborne protozoan causing amebic keratitis and granulomatous amebic encephalitis. Knema retusa extracts possess diverse biological activities. Niosomes, PEG-b-PCL micelles, and their combination were used to load KRe extract and tested for effects on Acanthamoeba viability, adherence, and cytotoxicity. KRe-loaded niosomes showed higher yield (87.93 ± 6.03%), larger size (199.3 ± 29.98 nm), and higher drug loading (19.63 ± 1.84%) than PEG-b-PCL (45.2 ± 10.07 nm, 2.15 ± 0.25%). The combination showed higher encapsulation efficiency (79.67 ± 2.08%). KRe-loaded niosomes and PEG-b-PCL plus niosome inhibited 90–100% of trophozoites for 72 h and reduced adhesion by 40–60% at 0.125–0.25 mg/mL. Cell viability exceeded 80% at 0.125 mg/mL, demonstrating low toxicity.
| Item Type: | Article |
|---|---|
| Subjects: | |
| Divisions: | Medicine > Vinayaka Mission's Medical College and Hospital, Karaikal |
| Depositing User: | Unnamed user with email techsupport@mosys.org |
| Last Modified: | 27 Nov 2025 06:45 |
| URI: | https://vmuir.mosys.org/id/eprint/1769 |
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