Chronic alcohol exposure significantly influences the prognosis and diagnosis of alcohol related liver disease (ALD), affecting gene expression and liver function. Hepatic proteins and non-coding RNAs are essential for many biological functions and disease progression. Regulatory processes associated with microRNAs and long non-coding RNAs (lncRNAs) are known enhanced by recent advances in RNA sequencing methods. This new importance of lncRNAs in hepatic disease progression encompasses their involvement in cellular growth, and regulation, necrosis, and the control of transcriptional factors. Regulation of cellular integrity and ECM accumulation are two of the many functions played by lncRNAs in hepatic fibrosis, a wound healing process characterized by the gradual formation of ECM during disease progression. In the context of hepatic disease progression, a multitude of lncRNAs actively participate in regulating cellular homeostasis, positioning them as potential therapeutic targets and valuable biomarkers in clinical practice. Acquiring insightful knowledge about the underlying biological processes and molecular mechanisms governing hepatic injuries is crucial for identifying specific and sensitive molecules that can facilitate hepatic regeneration. The studies are increasingly interested in understanding the function of lncRNAs in liver regeneration after long-term alcohol use. To better understand alcoholic liver disease clinically, this review seeks to clarify the predictive significance of lncRNAs regulatory factors in stimulating hepatic development and revitalization. © 2024 Elsevier B.V., All rights reserved.