This study aimed to compare the Baska mask and the endotracheal tube, two devices used to manage patient airways during laparoscopic surgery. Fifty patients undergoing laparoscopic cholecystectomy were randomly assigned to receive either the Baska mask or the endotracheal tube. Data on patients’ demographic and physical status, as well as their heart rate, blood pressure, oxygen level, and ease of device insertion, were collected. The mean BMI for the Baska mask group was 24.68 kg/m2 (± 4), and for the Endotracheal tube group, it was 24.83 kg/m2 (± 4.14), showing no significant difference (P = 0.9768). However, significant differences were observed in hemodynamic parameters. Patients in the endotracheal tube group exhibited higher heart rates, blood pressure, and mean arterial pressure, indicating more cardiovascular stress than those in the Baska mask group. The endotracheal tube also caused more throat irritation, with more patients reporting post-surgery sore throat. The Baska mask was found to be easier and quicker to insert, requiring less skill and time. Both devices provided adequate oxygenation, but the endotracheal tube had more negative effects on the cardiovascular system and throat. In conclusion, the Baska mask could be a better alternative for laparoscopic surgery, improving both physiological parameters and patient comfort. © 2024 Elsevier B.V., All rights reserved.