The study's objective was to assess the Indoor Environmental Quality (IEQ) of 32 naturally ventilated classrooms using spider monkey metaheuristic regression in Bangalore, India. These classrooms, which had a total seating capacity of 805 students, were selected from various educational institutions throughout southern India. The researchers evaluated PM2.5 levels, carbon dioxide levels, water vapor levels, and ozone levels as factors. They used the spider monkey approach for multilinear regression analysis. The findings revealed that individuals are willing to tolerate higher temperatures for better Indoor Air Quality (IAQ). However, it is crucial to consider all aspects of IEQ, as dissatisfaction with a single component may not lead to widespread discomfort unless it is a significant issue. By identifying the most critical building controls, designers can ensure their clients' comfort. © 2025 Elsevier B.V., All rights reserved.