Mechanically ventilated patients in intensive care units (ICUs) often suffer from severe, life-threatening conditions that need close monitoring and precise therapeutic interventions. Biomarkers are crucial in investigating the prognosis, guiding treatment decisions, and predicting outcomes in these critically ill patients. Among these biomarkers, the Lactate to Albumin Ratio (LAR) and the C-Reactive Protein to Albumin Ratio (CAR) have emerged as significant predictors of morbidity and mortality. The present study focuses on conducting a comparative analysis of LAR versus CAR in mechanically ventilated patients. An observational study was conducted on 50 mechanically ventilated patients, aged between 25 to 80 years, in the intensive care unit (ICU). The serum biomarkers like Lactate, CRP and albumin levels, were measured upon admission to the intensive care unit (ICU). Additionally, the other outcomes were assessed such as ICU mortality and length of stay. The findings revealed that the mean age of the patient was 55.64±16.52 years. Both the lactate-to-albumin ratio (0.70) and the CRP-to-albumin ratio (0.69) were significantly associated with ICU mortality. The p values of these two parameters were 0.03 and 0.04 respectively in lactate to albumin ratio and CRP to albumin ratio. The lactate-to-albumin ratio was more strongly correlated with markers of metabolic stress and tissue hypoxia, while the CRP-to-albumin ratio was a stronger predictor of inflammation severity. Both ratios provide valuable prognostic insights for mechanically ventilated patients. However, the lactate to albumin ratio is more indicative of metabolic stress and CRP to albumin ratio reflects inflammatory status, with lactate to albumin ratio being a more reliable indicator of prognosis in mechanically ventilated patients. © 2025 Elsevier B.V., All rights reserved.