The family Lamiaceae includes aromatic medicinal plants of ethnomedicinal value and many of them are widely used in traditional medicine to treat inflammatory and painful conditions. The current article intends to put forward a comparative analysis of antioxidant and anti-inflammatory activities of alcoholic extracts of whole plants of Coleus malabaricus and its morphotype with the most studied and well-documented plants of the genus Coleus (Family: Lamiaceae), Coleus zeylanicus and Coleus amboinicus by various in-vitro methods. The preliminary phytochemical screening of the plant extracts showed phytoconstituents such as steroids, alkaloids, flavonoids, phenolic compounds, and tannins. The total phenolic and flavonoid content of alcoholic extracts was determined by Folin-Ciocalteu and aluminum chloride colorimetric assays, respectively. The antioxidant potential was screened using hydroxy radical scavenging assay, nitric oxide radical scavenging assay, and anti-inflammatory activity by in-vitro protein denaturation and lipoxygenase inhibition method. All the extracts exhibited anti-inflammatory activity in a dose-dependent manner. Comparable results have been obtained at higher concentrations with the standard drug diclofenac. The antioxidant and anti-inflammatory activities are correlated well with the phenolic and flavonoid content. The ethanolic extracts of these Coleus plants thus exhibited good anti-inflammatory and antioxidant potential and may be an important source of novel antioxidant and anti-inflammatory agents. © 2025 Elsevier B.V., All rights reserved.