Development and Evaluation of Chitosan Nanoparticle-Loaded Films for Enhanced Bioavailability

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Priya P, Venkata Durga Seshu and S, Ruby and M, Kumar (2025) Development and Evaluation of Chitosan Nanoparticle-Loaded Films for Enhanced Bioavailability. International Journal of Drug Delivery Technology. ISSN 09754415

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Abstract

Memantine-loaded chitosan nanoparticles (MNPs) were formulated via ionic gelation and incorporated into buccal films (MNBF6) to enhance permeability and bioavailability. Optimized nanoparticles showed high entrapment efficiency (84.73%) and non-Fickian drug release. Buccal films demonstrated superior mucoadhesion, mechanical strength, and sustained drug release, suggesting a viable alternative delivery system for Alzheimer's disease management.

Item Type: Article
Subjects: Pharmacology, Toxicology and Pharmaceutics > Pharmaceutical Science
Divisions: Engineering and Technology > Aarupadai Veedu Institute of Technology, Chennai > Electronics & Communication Engineering
Depositing User: Unnamed user with email techsupport@mosys.org
Date Deposited: 25 Nov 2025 08:46
Last Modified: 25 Nov 2025 08:46
URI: https://vmuir.mosys.org/id/eprint/1005

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